A Stability Pattern of Protein Hydrophobic Mutations that Reflects Evolutionary Structural Optimization
نویسندگان
چکیده
منابع مشابه
What makes a protein a protein? Hydrophobic core designs that specify stability and structural properties.
Here we describe how the systematic redesign of a protein's hydrophobic core alters its structure and stability. We have repacked the hydrophobic core of the four-helix-bundle protein, Rop, with altered packing patterns and various side chain shapes and sizes. Several designs reproduce the structure and native-like properties of the wild-type, while increasing the thermal stability. Other desig...
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In this paper, multi-objective optimization of railway wheel web profile using bidirectional evolutionary structural optimization (BESO) algorithm is investigated. Using a finite element software, static analysis of the wheel based on a standard load case, and its modal analysis for finding the fundamental natural frequency is performed. The von Mises stress and critical frequency as the proble...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2005
ISSN: 0006-3495
DOI: 10.1529/biophysj.105.067025